Main Street Medical Centre is located at the end (Suite 6) of a collection of blue buildings called the Merimbula Professional Centre at 93 Main Street in Merimbula. This is next to St Clements Anglican Church and opposite the Merimbula RSL club car park on Main Street.

Car parking is at the rear of the building. Wheelchair access is available from the top end of the Medical Centre next to Radiology. Disabled parking is available.